Detoxing
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The Facts About Glutathione and Parkinsons Disease
   
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Naturopathic Medicine
Naturopathic Medicine is an holistic approach that relies on natural remedies. Sunlight, air, and water are thought of as natural healers; this, along with nutritional supplements and .....
Naturopathic Medicine is an holistic approach that relies on natural remedies. Sunlight, air, and water are thought of as natural healers; this, along with nutritional supplements and .....
Copyright 2004 Priya Shah
Parkinson's Disease (PD), a devastating illness, occurs in one
of every 100 people over 65.
It is a slowly progressing disease of the nervous system that
results in progressive destruction of brain cells (neurons) in
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an area of the brain called the substantia nigra. Death occursDealing with all of the environmental toxins today, can be quite
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usually as a result of secondary complications such as
infection.
One of the mechanisms known to destroy neurons is damage by free
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produced by oxidation of the neurotransmitter dopamine.
The Role of Dopamine
The cells of the substantia nigra use dopamine - a chemical
messenger between brain or nerve cells - to communicate with
cells in another region of the brain called the striatum.
When nigral cells are lost, nigral dopamine levels fall,
resulting in a decrease in striatal dopamine.
The typical symptoms of PD - motor function deficiencies
characterized by muscle rigidity, jerky movements, rhythmic
resting tremors - are the result of low levels of striatal
dopamine.
Most dopaminergic drugs used to treat PD, are aimed at
temporarily replenishing or mimicking dopamine. They improve
some symptoms, but do not restore normal brain function nor halt
brain cell destruction.
Dopaminergic drugs are generally effective at first in reducing
many PD symptoms, but over time they lose their effect.
They also cause severe side effects because they overstimulate
nerve cells elsewhere in the body and cause confusion,
hallucinations, nausea and fluctuations in the movement of
limbs.
The Role of Antioxidants
When dopaminergic neurons are lost in the course of Parkinson's
disease, the metabolism of dopamine is increased - which in turn
increases the formation of highly neurotoxic hydroxyl radicals.
The most important free radical scavenger in the cells of the
substantia nigra is the powerful brain antioxidant, glutathione.
Glutathione levels in PD patients are low.
And as we age, levels of glutathione in the dopaminergic neurons
of the substantia nigra decreases. This appears to hasten cell
death and advance the progression of PD.
At least 80 percent of the substantia nigra cells are lost
before symptoms of Parkinson's disease become apparent. This is
why it becomes essential to protect or maintain these cells
under oxidative stress.
How does Glutathione help in Parkinson's Disease?
Several factors explain why glutathione is so beneficial in
Parkinsons disease.
1. Glutathione increases the sensitivity of the brain to
dopamine. So although glutathione doesn't raise dopamine levels,
it allows the dopamine in the brain to be more effective.
2. Glutathione's powerful antioxidant activity protects the
brain from free radical damage.
3. An even more intriguing benefit of glutathione lies in its
powerful detoxification ability.
Its a well known fact that most Parkinsons patients are
deficient in their ability to detoxify chemicals to which they
are exposed.
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The unfortunate few who harbor an inherited flaw in their
detoxification pathways are at far greater risk to the brain
damaging effects of a wide variety of toxins.
Glutathione is one of the most important components of the
livers detoxification system. Glutathione therapy is one of the
most effective techniques for enhancing liver and brain
detoxification.
Glutathione treatments considerably improve some of the symptoms
of Parkinson's disease including difficulties with rigidity,
walking, movement, coordination and speech. A marked reduction
of tremor has been observed as well as a decrease in depression.
Glutathione and N-acetyl-L-cysteine (a glutathione precursor)
have been shown to be very effective in protecting the nerves in
the substantia nigra from being destroyed by oxidative stress.
Glutathione Therapy in Parkinson's Disease
The practical problem in increasing glutathione levels is that
taking glutathione itself as a supplement does not boost
cellular glutathione levels, since glutathione breaks down in
the digestive tract before it reaches the cells.
However, intravenous glutathione therapy and taking glutathione
precursors are both effective in boosting intracellular levels
of glutathione.
Intravenous Glutathione Therapy:
Intravenous glutathione injections have been shown to have
amazing and quick results.
Dr. David Perlmutter, a pioneer in this therapy, has developed a
protocol utilized at the Perlmutter Health Center for
administering intravenous glutathione to Parkinson's patients.
Following even a single dosage of intravenous glutathione -
often in as little as 15 minutes - the ability to walk, turn
around and move their arms is almost completely restored.
Glutathione Precursors:
Dietary antioxidants and supplements that increase cellular
glutathione, such as alpha lipoic acid, NAC, pycnogenol, the
herb silymarin (milk thistle), are effective in restoring normal
function.
N-acetyl-cysteine (NAC) and un-denatured, whey protein both
supply glutathione precursors intracellularly, enhance the
bodys production of glutathione and aid the detoxification
process.
Other nutritional supplements which aid the detoxification
process include selenium, vitamins E and C.
For a detailed report with references on Parkinson's Disease and
Glutathione visit:
http://www.1whey2health.com/parkinsons_glutathione.htm
About the author:
Priya Shah is the Editor of "The Glutathione Report" For regular
updates on the health benefits of glutathione subscribe here
http://www.glutathione-report.com For a free report on
Glutathione in Health and Disease visit
http://www.1whey2health.com